From the parking garage, turn right (north) upon entering and continue toward the back wall. From the main front entrance, turn right, head toward the east wall, then turn left (north) and head to the back.
The poker room is located in the back right (northeast) corner of the casino.
Coming south from Memphis or the I-69 junction, this will be a right turn on Casino Center. The Horseshoe is part of the Casino Center complex, along with the Sheraton and the Gold Strike.